WCP2018 KYOTO / 18th WORLD CONGRESS OF BASIC AND CLINICAL PHARMACOLOGY

Pharmacology for the Future -Science, Drug Development and Therapeutics-

July1(Sun)-6(Fri),2018 Kyoto International Conference Center Kyoto, Japan

Scientific Program

Program at a glance

Program

As of October 3, 2017 - subject to change

Timetable

AM PM
July 1 - Opening Ceremony
Opening Lecture
Opening Symposium
Welcome Reception
July 2 Plenary Lecture 1
Cutting Edge Lectures
Symposia
Symposia
Oral Sessions
Poster Sessions
Luncheon Seminars
July 3 Plenary Lecture 2
Cutting Edge Lectures
Symposia
Tang Prize Lecture
Symposia
Oral Sessions
Poster Sessions
Luncheon Seminars
July 4 Plenary Lecture 3
Cutting Edge Lectures
Symposia
Analytical Pharmacology Lecture
Symposia
Oral Sessions
Poster Sessions
Luncheon Seminars
July 5 Plenary Lecture 4
Symposia
Symposia
Cutting Edge Lectures
Oral Sessions
Poster Sessions
Luncheon Seminars
Gala Dinner (Ticketed Event)
July 6 Symposia
Closing Ceremony
-

Opening Lecture

Tasuku Honjo, M.D., Ph.D.

Cancer Immunotherapy (tentative) Sunday, July 1, 2018   16:00-17:00

Tasuku Honjo, M.D., Ph.D.
Kyoto University, Japan

Plenary Lecture

Shinya Yamanaka, M.D., Ph.D.

1. Recent Progress in iPS Cell Research and Application Monday, July 2, 2018   11:15-12:15

Shinya Yamanaka, M.D., Ph.D.
Kyoto University, Japan

Karl Deisseroth, M.D., Ph.D.

2. Optogenetics (tentative) Tuesday, July 3, 2018   11:15-12:15

Karl Deisseroth, M.D., Ph.D.
Stanford University, USA

Nancy J. Brown, M.D.

3. The Cardiovascular Effects of Peptidase Inhibition Wednesday, July 4, 2018   11:15-12:15

Nancy J. Brown, M.D.
Vanderbilt University Medical Center, USA

Adam Cohen, M.D., Ph.D.

4. Drug Development as an Outcome of Integration of Basic and Clinical Pharmacology Thursday, July 5, 2018   11:15-12:15

Adam Cohen, M.D., Ph.D.
Center for Human Drug Research, The Netherlands

Tang Prize Lecture

Feng Zhang, Ph.D.

Genome Engineering: Technologies and Applications Tuesday, July 3, 2018   17:00-18:00

Feng Zhang, Ph.D.
McGovern Institute for Brain Research, USA

Analytical Pharmacology Lecture

Bryan L. Roth M.D., Ph.D.

Towards a Molecular Understanding of Drug Action at GPCRs Wednesday, July 4, 2018   17:00-18:00

Bryan L. Roth M.D., Ph.D.
University of North Carolina at Chapel Hill, USA

Opening Symposium

Pharmacology, Translational Medicine and Drug Discovery Sunday, July 1, 2018   17:00-18:40

Makoto Suematsu, MD, PhD

Mission of AMED: Global data sharing and medical R&D

Makoto Suematsu, MD, PhD
Japan Agency for Medical Research and Development (AMED), Japan

Garret A. Fitzgerald, MD, FRS

TBA

Garret A. Fitzgerald, MD, FRS
Perelman School of Medicine, University of Pennsylvania, USA

Pierre Meulien

Open Innovation through a public-private partnership – The Innovative Medicines Initiative

Pierre Meulien
Executive Director, the Innovative Medicines Initiative (IMI)

Isao Teshirogi

TBA

Isao Teshirogi
Vice President of the Japan Pharmaceutical Manufacturers Association (JPMA) President and Chief Executive Officer, Shionogi & Co., Ltd., Japan

Cutting Edge Lectures

Confirmed Speakers (Presentation themes are tentative.)

Within each category, in alphabetical order by speaker’s name.

■ Neuroscience

Molecular Imaging for Diagnosis and Treatment of Neurodegenerative Disorders at a Prodromal Stage Monday, July 2, 2018   8:30-9:15

Makoto HiguchiNational Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Japan

Neurobiology of Stress, Depression, and Antidepressants:
Rapid Remodeling of Synaptic Connections
Monday, July 2, 2018   8:30-9:15

Ronald S. DumanDepartment of Psychiatry, Yale University School of Medicine, USA

Structure, Function and Pharmacology of Na+ and Ca2+ Channels at Atomic Resolution Tuesday, July 3, 2018   8:30-9:15

William A. CatterallDepartment of Pharmacology, University of Washington, USA

Brain-imaging for the Treatment of Psychiatric Diseases Wednesday, July 4, 2018   8:30-9:15

Shigeto YamawakiDepartment of Psychiatry and Neurosciences, Hiroshima University/ Center of Innovation(COI), Japan
■ Pain

TBA Monday, July 2, 2018   8:30-9:15

Stephen B. McMahonKing's College London, UK
■ Cardiovascular System

TBA Monday, July 2, 2018   8:30-9:15

Baofeng YangDepartment of Pharmacology, College of Pharmacy, Harbin Medical University, China
■ Nephrology and Urology

Rethinking Sodium Metabolism Monday, July 2, 2018   8:30-9:15

Jens M. TitzeDivision of Clinical Pharmacology, Vanderbilt University Medical Center, USA
■ Immunology, Inflammation and Bone Metabolism

RANKL-From Basic Discovery to Clinical Application Wednesday, July 4, 2018   8:30-9:15

Josef PenningerIMBA-Institute of Molecular Biotechnology, Austria

Control of Immune Responses by Regulatory T Cells Thursday, July 5, 2018   8:30-9:15

Shimon SakaguchiDepartment of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University, Japan

Biologics Versus Small Molecules in Treatment of Systemic Autoimmune Diseases Thursday, July 5, 2018   15:05-15:50

Masataka KuwanaDepartment of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Japan
■ Gastrointestinal System

NSAID-induced Gastrointestinal (GI) Damage and the Design of GI-sparing NSAIDs Wednesday, July 4, 2018   8:30-9:15

John L. WallaceDepartment of Physiology & Pharmacology, University of Calgary, Canada
■ Stem Cell Medicine

Human Pluripotent Stem Cells in Neurological Disease Modeling and Drug Discovery Wednesday, July 4, 2018   8:30-9:15

Haruhisa InoueCiRA, Kyoto University, Kyoto, Japan
■ Metabolism and Diabetes

Molecular Mechanism of Type 2 Diabetes: Perspectives from Insulin Receptor and
Adiponectin Receptor Actions
Thursday, July 5, 2018   8:30-9:15

Takashi KadowakiDepartment of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Japan
■ Respiratory System

Phospholipids Metabolism in Health and Disease Thursday, July 5, 2018   8:30-9:15

Takao ShimizuDepartment of Lipid Signaling, National Center for Global Health and Medicine/University of Tokyo Faculty of Medicine, Japan
■ Systems Biology

Systems Pharmacology and Translational Therapeutics Monday, July 2, 2018   8:30-9:15

Garret A. FitzgeraldPerelman School of Medicine, University of Pennsylvania, USA
■ Education and Training

Prescribing Safety Assessment: Ensuring Competency of New Doctors to Use Medicines Tuesday, July 3, 2018   8:30-9:15

Simon MaxwellUniversity of Edinburgh, UK
■ Sensory System

Lipid Mediators: Function and Therapeutic Target for Ocular Diseases Tuesday, July 3, 2018   8:30-9:15

Makoto AiharaDepartment of Ophthalmology, The University of Tokyo, Japan
■ Cancer

TBA Tuesday, July 3, 2018   8:30-9:15

John A. HartleyUCL Cancer Institute, USA
■ Molecular Bioimaging

Positron Emission Tomography of Human Brain can Monitor Neuroinflammation and
cAMP Signaling: Applications to Alzheimer's Disease and Depression
Thursday, July 5, 2018   8:30-9:15

Robert B. InnisNational Institute of Mental Health, USA
■ Infection/Global Infectious Diseases

Drug Discovery for Neglected Diseases Wednesday, July 4, 2018   8:30-9:15

Ian GilbertDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, UK
■ Natural Medicine and Traditional East Asian Medicines

Pharmacological Action and Mechanism of Traditional Chinese Medicine Wednesday, July 4, 2018   8:30-9:15

Yongxiang ZhangBeijing Institute of Pharmacology and Toxicology, China
■ Regulatory Science

PMDA's Initiatives Based on Regulatory Science.
In Pursuit of Developing Innovative Drugs and Medical Devices
Monday, July 2, 2018   8:30-9:15

Tatsuya KondoPharmaceuticals and Medical Devices Agency (PMDA), Japan
■ Pharmacovigilance

Therapeutic Validation of Rasna Panchaka, Poly Herbal Formulation and
Sheer Pak by ‘Reverse Pharmacology (RP)’ Tool
Wednesday, July 4, 2018   8:30-9:15

B. Dinesh KumarHOD Drug Toxicology Division, National Institute of Nutrition, India
■ Health Economics

Cost-effectiveness Analysis for Health Policy Making in Japan Tuesday, July 3, 2018   8:30-9:15

Shunya IkedaSchool of Medicine, International University of Health and Welfare, Japan
■ Toxicology

Microbiome and Epigenetic Effects on Xenobiotic Processing Genes Thursday, July 5, 2018   8:30-9:15

Curtis D. KlaassenUniversity of Washington, USA
■ Pharmacometrics

Future of Pharmacometrics Tuesday, July 3, 2018   8:30-9:15

Joga GobburuProfessor of Pharmacy Practice and Science Director, Center for Translational Medicine University of Maryland, USA
■ Pharmacokinetics

Pharmacokinetic Changes Across the Developmental Trajectory Wednesday, July 4, 2018   8:30-9:15

Shinya ItoHospital for Sick Children, University of Toronto, Canada
■ Cross-Sectoral

Structural Biology of P-type ATPases Monday, July 2, 2018   8:30-9:15

Chikashi ToyoshimaInstitute of Molecular and Cellular Biosciences, The University of Tokyo, Japan

The Role of Public Sector Research in the Discovery of Drugs and Vaccines - an Update Tuesday, July 3, 2018   8:30-9:15

Ashley J. StevensFocus IP Group, LLC, USA

GPCR Allostery and Bias in Modern Pharmacology:
Structural, Pharmacological and Clinical Implications
Wednesday, July 4, 2018   8:30-9:15

Arthur ChristopoulosMonash Institute of Pharmaceutical Sciences, Monash University, Australia

Differential Clinical Impacts of Oxidative Stress and Nitrosative Stress:
Therapeutic Implications
Thursday, July 5, 2018   8:30-9:15

Samuel H.H. ChanInstitute for Translational Research in Biomedicine, Chang Gung Memorial Hospital, Taiwan

Unconventional Secretion of Membrane Protein Thursday, July 5, 2018   8:30-9:15

Min Goo LeeYonsei University, College of Medicince, Korea
■ Pharmacology for Africa

Ethics and Cutting-Edge Pre-clinical Research: An African Perspective Tuesday, July 3, 2018   8:30-9:15

Christiaan B BrinkSchool of Pharmacy, North-West University, South Africa

Symposia (85 sessions)

*Title of presentations are tentative.

■ Neuroscience
Alzheimer's Disease; Toward Very Early Diagnosis and Treatment Monday, July 2, 2018   9:25-11:05
Organizer:Takeshi Iwatsubo Department of Neuropathology School of Medicine, The University of Tokyo, Japan
Speakers: Very early treatment of Alzheimer's disease: experiences in J-ADNI and A4 study
Takeshi Iwatsubo Department of Neuropathology School of Medicine, The University of Tokyo, Japan
Crossing the threshold: determinants of rates of progression in preclinical Alzheimer's disease
Colin L. Masters Florey Institute, The University of Melbourne, Australia
Anti-Abeta antibodies as a disease modifying therapy against Alzheimer's disease
Eric Siemers Eli Lilly and Company, Indianapolis, IN, USA
Drug Design Based on 3D Microstructure of Receptors Monday, July 2, 2018   9:25-11:05
Organizer:Yuji Ikegaya The University of Tokyo, Japan
Speakers: Functional dynamics of membrane proteins by NMR
Ichio Shimada Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Drug Rescuing by cryo-EM
Yoshinori Fujiyoshi CeSPI, Nagoya University, Furo-cho, Chikusa, Nagoya, Japan
Visualizing small molecule binding in membrane proteins by single particle cryo-EM
Yifan Cheng HHMI/Biochemistry & Biophysics, University of California, USA
Glia-targeted Therapies: New Technical Advances for Seeing and Manipulating Glial Functions in the Brain Diseases Monday, July 2, 2018   13:50-15:30
Organizer:Schuichi Koizumi Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Japan
Speakers: Glial MAOb and Alzheimer's disease
Changjoon Justin Lee Korea Institute of Science and Technology (KIST), Seoul, Korea
Purine signaling in glial cells: Physiological and pathological relevance
Shumin Duan Zhejiang University School of Medicine, China
Astrocyte-synapse interaction in health and diseases
Schuichi Koizumi Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Japan
Transformative Technologies at the Forefront of Brain Research Monday, July 2, 2018   16:10-17:50
Organizer:Haruhiko Bito Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Japan
Speakers: Dissecting neuronal circuit functions using next-generation genetically encoded Ca2+ indicators (GECIs)
Haruhiko Bito Department of Neurochemistry, The University of Tokyo Graduate School of Medicine, Japan
All-optical interrogation of neuronal circuits
Adam E. Cohen Harvard University, USA
Optogenetic, tissue clearing, and viral vector approaches to understand and influence whole-animal physiology and behavior
Viviana Gradinaru Caltech - California Institute of Technology, USA
ADHD and Substance Use Disorders: Epidemiology, Neurobiology and Treatment Monday, July 2, 2018   16:10-17:50
Organizer:Wim van den Brink Department of Psychiatry, Academic Medical Center University of Amsterdam, The Netherlands
Speakers: The role of CD and depression in the development of addiction in youngsters with ADHD
Kouichi Yoshimasu Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama, Japan
The genetics of ADHD and substance use disorders
J. Antoni Ramos-Quiroga Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Spain
Neurobiology of ADHD and comorbid substance use disorders
Wim van den Brink Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Treatment of patients with ADHD and substance use disorder
Pieter-Jan Carpentier Reinier van Arkel Mental Health Institute, 's-Hertogenbosch, The Netherlands
Ca2+ Signaling in Health and Disease Tuesday, July 3, 2018   9:25-11:05
Organizers:Haruhiko Bito Department of Neurochemistry, Graduate School of Medicine, The University of Tokyo, Japan
Gary Stephens University of Reading, UK
Chairs: Gary Stephens University of Reading, UK
Sumiko Mochita Tokyo Medical University, Japan
Speakers: Calcium signaling and presynaptic vesicle release
Sumiko Mochida Department of Physiology, Tokyo Medical University, Japan
Voltage gated calcium channels as molecular targets for pain therapeutics
Gerald W. Zamponi Cumming School of Medicine, University of Calgary, Canada
Functional Interaction between Ca22+-permeable TRP channels and Ca2+-activated chloride channel, anoctamin 1
Makoto Tominaga Division of Cell Signaling, Okazaki Institute for Integrative Bioscience, Japan
The role of N-type calcium channels and their auxiliary subunits in pain pathways
Annette C. Dolphin Department of Neuroscience Physiology and Pharmacology, University College London, UK
Recent Advances in the Development of Subtype-selective and Signaling-biased Drugs for
D2-like Dopamine Receptors: Towards Improved Therapeutics for Neuropsychiatric Disorders
Tuesday, July 3, 2018   15:10-16:50
Organizer:David R. Sibley Molecular Neuropharmacology Section National Institute of Neurological Disorders & Stroke/NIH, USA
Speakers: Novel D2 receptor-selective antagonists and biased agonists for the treatment of neuropsychiatric disorders
David R. Sibley National Institute of Health, USA
Beyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug design
Amy H. Newman National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, USA
Harnessing allostery as a novel approach to target the D2-like dopamine receptors
J. Robert Lane Monash Institute of Pharmaceutical Sciences, Monash University, Australia
How high resolution x-ray crystal structures of D2-like dopamine receptors can guide the development of novel subtype-selective drugs
Bryan L. Roth Department of Pharmacology, University of North Carolina at Chapel Hill, USA
Novel Approaches Towards Understanding Psychiatric Disorders: Inflammation in the Brain and Periphery Wednesday, July 4, 2018   9:25-11:05
Organizer:Tomoyuki Furuyashiki Division of Pharmacology, Kobe University Graduate School of Medicine, Japan
Speakers: Roles of monocyte trafficking from the periphery to the brain in repeated stress-induced emotional changes
John F. Sheridan Ohio State University College of Medicine, USA
Neuroimmune mechanisms of depression
Scott Russo Icahn School of Medicine at Mount Sinai, USA
Roles of gut microbiota and inflammation in psychopathology
John F. Cryan University College Cork, Cork, Ireland
Multiple roles of inflammation-related molecules in stress-induced emotional changes
Tomoyuki Furuyashiki Division of Pharmacology, Kobe University Graduate School of Medicine, Japan
Emerging Therapeutic Targets Against Autism Spectrum Disorder Wednesday, July 4, 2018   15:10-16:50
Organizer:Chan Young Shin Department of Pharmacology, School of Medicine, Konkuk University, Korea
Speakers: Emerging therapeutic targets against ASD based on E/I imbalance hypothesis
Chan Young Shin Department of Pharmacology, School of Medicine, Konkuk University, Korea
Using genetic mouse models to identify therapeutic targets for ASD
Olga Penagarikano Department of Pharmacology, School of Medicine, University of the Basque Country, Leioa, Spain
GABAergic Neurophysiology and Socio-communicative Abilities in Adults with Autism Spectrum Disorder
Lawrence Fung Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, USA
Therapeutic potential of oxytocin against ASD: preclinical and clinical evidences
Hidenori Yamasue Department of Psychiatry, Hamamatsu University School of Medicine, Japan
Shortened Life Span in Patients with Schizophrenia:
Life Style Related Problems and Clinical Pharmacology of Antipsychotics
Thursday, July 5, 2018   9:25-11:05
Organizer:Kazutaka Shimoda Department of Psychiatry, Dokkyo Medical University, Japan
Speakers: Physical risks in Japanese patients with schizophrenia: Current status in Japan
Takuro Sugai Niigata University Graduate School of Medical and Dental Sciences, Japan
Metabolic syndrome and dietary pattern in schizophrenia: what is the effective intervention?
Norio Yasui-Furukori Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Japan
Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders
Christoph U. Correll Hofstra Northwell School of Medicine, New York, USA, and Charite School of Medicine, Berlin, USA/Germany
Alpha-synuclein in Parkinson's Disease Thursday, July 5, 2018   9:25-11:05
Organizer:Masahiro Nomoto Ehime University, Japan
Speakers: α-synuclein and familial Parkinson's disease
Nobutaka Hattori Department of Neurology, Juntendo University, Japan
Alpha-synuclein in Parkinson's disease and related disorders
Masato Hasegawa Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan
A new role for α-synuclein in synucleoinopathies: Alteration of ER-mitochondria communication
Cristina Guardia-Laguarta Department of Pathology and Cell Biology, Columbia University, NY, USA
Mechanisms of Maladaptive Plasticity in Animal Models of Neuropsychiatric Disorders Thursday, July 5, 2018   16:10-17:50
Organizer:Maurizio Popoli Department of Pharmacological and Biomolecular Sciences - University of Milano, Italy
Speakers: Modulation of microRNAs in rat models of acute and chronic stress
Laura Musazzi Laboratory of Neuropsychopharmacology and Functional Neurogenomics – Dipartimento di Scienze Farmacologiche e Biomolecolari and Center of Excellence on Neurodegenerative Diseases, Università di Milano, Milano, Italy
Post-ischemic depression and the hippocampal neurodegeneration.
Jiro Kasahara Department of Neurobiology and Therapeutics, Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, Japan
Replenishment of microRNA-188-5p restores the synaptic and cognitive deficits in 5XFAD Mouse Model of Alzheimer's Disease.
Hye-Sun Kim Seoul National University, College of Medicine, Department of Pharmacology, Korea
Sexually dimorphic “pre-stressed” translational signature in CA3 pyramidal neurons of BDNF Val66Met mice.
Jordan Marrocco The Rockefeller University Laboratory of Neuroendocrinology, New York, USA
Brain-Gut Axis Thursday, July 5, 2018   16:10-17:50
Organizer:Ludmila Filaretova Pavlov Institute of Physiology, Russia
Speakers: Brain peptides and vagal modulation of gastric inflammation
Yvette Taché UCLA Digestive Diseases Division, USA
The HPA system is a key hormonal component of the brain-gut axis
Ludmila Filaretova Pavlov Institute of Physiology, Russian Academy of Sciences, Russia
Gut microbiota regulation of brain & behaviour
John F. Cryan University College Cork, Cork, Ireland
Role of the brain-gut axis in irritable bowel syndrome
Shin Fukudo Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Novel Regulations and Functions of Dopaminergic Systems Towards Understanding Psychiatric Disorders Friday, July 6, 2018   8:30-10:10
Organizer:Tomoyuki Furuyashiki Division of Pharmacology, Kobe University Graduate School of Medicine, Japan
Speakers: Novel dopamine receptor signaling in the striatum and its functional implications
Kozo Kaibuchi Nagoya University Graduate School of Medicine, Japan
Dopamine actions on the dendritic spines for reward and aversive learning in the nucleus accumbens
Haruo Kasai Graduate School of Medicine, The University of Tokyo, Japan
Roles and regulations of dopaminergic pathways in repeated stress-induced emotional changes
Ming-Hu Han Department of Pharmacological Sciences Icahn School of Medicine at Mount Sinai, USA
Dynamics of dopamine release in the striatum and its alterations with psychiatric pathology
Paul E.M. Phillips University of Washington, USA
New Perspective on the Function and Pharmacology of the Renin-angiotensin System Friday, July 6, 2018   10:20-12:00
Organizers:Clare Stanford UCL IRIS, UK
Speakers: Pleiotropic mechanisms and actions of the brain renin-angiotensin system
Robert C. Speth College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL; Department of Pharmacology and Physiology, College of Medicine, Georgetown University, Washington, DC, USA
An emerging role of angiotensin receptor binding protein ATRAP as a possible novel player in pathophysiology of visceral obesity and metabolic disorders
Kouichi Tamura Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Japan
The neuronal renin-angiotensin system: A new strategy for PTSD and fear related disorders
Paul J. Marvar The George Washington University, USA
Targeting the neuronal renin-angiotensin system in prevention of neurodegeneration and dementia
Ursula Quitterer Molecular Pharmacology Unit, Department of Chemistry and Applied Biosciences, ETH Zurich; Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
■ Pain
Pain Sensor Monday, July 2, 2018   9:25-11:05
Organizer:Yasuo Mori Graduate School of Engineering, Kyoto University, Japan
Speakers: Molecular Sensors for Noxious Temperature.
Thomas Voets Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, University of Leuven, Belgium
Sensing and repletion Mechanisms of Ca2+ stores
Reinhold Penner The Queen's Medical Center & University of Hawaii, Honolulu, USA
Role of TRPA1 in ischemia/reperfusion-induced painful dysesthesia and oxaliplatin-induced cold hypersensitivity
Shuji Kaneko Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Central Pain and Translation Monday, July 2, 2018   16:10-17:50
Organizer:Hiroshi Ueda Department of Pharmacology and Therapentic Innovation,
Nagasaki University Graduate School of Biomedical Sciences, Japan
Speakers: The endocannabinoid system modulates the affective component of chronic pain
Andreas Zimmer Institute of Molecular Psychiatry, University of Bonn, Germany
Lysophosphatidic acid signaling is involved in the development and maintenance of neuropathic pain and fibromyalgia
Hiroshi Ueda Department of Pharmacology and Therapeutic Innovation, Nagasaki University Graduate School of Biomedical Sciences, Japan
Pain and tumor immune response
Minoru Narita Department of Pharmacology; Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences, Japan
■ Cardiovascular System
Recent Advances in the Molecular and Cellular Understanding of Heart Failure
―Toward Novel Therapeutic Strategies
Monday, July 2, 2018   9:25-11:05
Organizer:Yasushi Fujio Laboratory of Clinical Science and Biomedicine Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Speakers: Somatic mutations that contribute to clonal hematopoiesis and cardiovascular disease risk: New mechanisms, new pharmacological targets
Kenneth Walsh Boston University School of Medicine, USA
Autophagy as a therapeutic target against heart faillure
Junichi Sadoshima New Jersey Medical School, USA
TRPC3 channels as a key regulator of cardiac plasticity
Motohiro Nishida Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Japan
Growth factor therapy to prevent postinfarction heart failure
Kai C. Wollert Department of Cardiology and Angiology, Division of Molecular and Translational Cardiology, Hannover Medical School, Hannover, Germany
Hypertension: New Developments in Understanding and Management Monday, July 2, 2018   16:10-17:50
Organizers:David J. Webb University of Edinburgh, UK
Neeraj Dhaun University of Edinburgh, UK
Speakers: Management of hypertension in chronic kidney disease
Neeraj Dhaun (Bean) University of Edinburgh, UK
Poor adherence to anti-hypertensive treatment: The elephant in the room
Una Martin University of Birmingham, UK
Prospects for novel therapeutic approaches to hypertension
David J. Webb Christison Professor of Therapeutics & Clinical Pharmacology, The University of Edinburgh, Scotland, UK
New Therapeutic Approach for Cardiorenal Syndrome-integration of Basic and
Clinical Pharmacological Evidence
Wednesday, July 4, 2018   15:10-16:50
Organizer:Akira Nishiyama Department of Pharmacology, Kagawa University Medical School, Japan
Speakers: Combined AT1 receptor/neprilysin inhibition (ARNI)
A.H.J. Danser Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Vaccines and biologics
Hironori Nakagami Department of Health Development and Medicine, Osaka University Graduate School of Medicine, Japan
Mineralocorticoid receptor blockers
Nancy J. Brown Vanderbilt University Medical Center, Department of Medicine, Hugh Jackson Morgan Professor of Medicine and Pharmacology, Vanderbilt Hospital, USA
SGLT2 inhibitor
Akira Nishiyama Department of Pharmacology, Kagawa University Medical School, Japan
Pharmacology and Clinical Pharmacology about Inflammation and
the Development of Atherosclerosis
Thursday, July 5, 2018   9:25-11:05
Organizer:Hiroshi Watanabe Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Japan
Speakers: Antiinflammatory therapy with colchicine for atherosclerotic carfiovascular disease
Shinichiro Ueda Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Japan
Endothelial function and Inflammation
Yukihito Higashi Hiroshima University, Japan
New Mechanisms of the G Protein-Coupled Estrogen Receptor 1 as a Moderator of Cardiovascular
Kim Tran Department of Physiology and Phamacology, Des Moines University college of Osteopathic Medicine, Des Moines, IA, USA
The role of endothelin in immune-mediated vascular injury
David J. Webb Christison Professor of Therapeutics & Clinical Pharmacology, The University of Edinburgh, Scotland, UK
Therapeutic Strategy to Enhance Intrinsic Resistance in Cardiovascular System Thursday, July 5, 2018   16:10-17:50
Organizer:Motohiro Nishida Division of Cardiocirculatory Signaling Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Japan
Speakers: Ca2+ signaling in pulmonary hypertension: Role of STIM2
Jason X.-J. Yuan The University of Arizona Health Sciences, USA
Coronary endothelial dysfunction in diabetes: Role of HuR
Ayako Makino Department of Physiology, The University of Arizona, USA
Purinergic P2Y6 receptors in cardiovascular stress resistance
Caroline Sunggip Faculty of Medicine & Health Sciences, University Malaysia Sabah, Kota Kinabalu Sabah, Malaysia
Ca2+-activated Cl- TMEM16A channel in portal hypertension
Hisao Yamamura Department of Molecular & Cellular Pharmacology, Nagoya City University Graduate School of Pharmaceutical Sciences , Japan
Endothelial Mechanosensing in Vascular Physiology and Disease Friday, July 6, 2018   8:30-10:10
Organizers:Naoki Mochizuki National Cerebral and Cardiovascular Center Research Institute, Japan
Stefan Offermanns Max Planck Institute for Heart and Lung Research, Germany
Speakers: Novel mechanosensors in endothelial cells
Ellie Tzima University of Oxford, Radcliffe Department of Medicine, UK
Endothelial Yap1 functions as a mechanotransducer to maintain blood vessels.
Naoki Mochizuki National Cerebral and Cardiovascular Center Research Institute, Japan
Regulation of vascular tone and blood pressure through endothelial mechanosignaling
Stefan Offermanns Max Planck Institute for Heart and Lung Research/ Goethe-University Frankfurt , Germany
Cutting Edge of Calcium Permeable Ion Channels in Diseases as Potential Targets of Drug Discovery Friday, July 6, 2018   10:20-12:00
Organizers:Yuji Imaizumi Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
David J. Beech University of Leeds, UK
Speakers: Physiology and pharmacology Piezo1 channels
David J. Beech University of Leeds, UK
CRAC channels as critical regulators of immunity to infection and inflammation
Stefan Feske New York University School of Medicine, USA
Ca2+ entry mechanisms in redox physiology
Yasuo Mori Kyoto University Graduate School of Engineering, Japan
Evidence for a protective role of TRPC5 in arthritis.
Susan Brain Vascular Biology & Inflammation Section, Cardiovascular Division, Kings College London, UK
■ Nephrology and Urology
New Pharmacological Approaches for Renal Diseases Monday, July 2, 2018   9:25-11:05
Organizer:Akira Nishiyama Department of Pharmacology, Kagawa University Medical School, Japan
Speakers: The gut microbiome as target for the treatment of cardiovascular disease
Dominik N. Müller Experimental and Clinical Research Center & Max-Delbrück Center, Germany
Genetic and epigenetic approaches for renal disease
Jihwan Park Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Intravital imaging of renal pathophysiology and pharmacology
Daisuke Nakano Department of Pharmacology, Kagawa University, Japan
iPS cells and renal pharmacological target
Kenji Osafune Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan
Lower Urinary Tract Dysfunction Update: New Insight into Pharmacological Mechanisms1 Thursday, July 5, 2018   16:10-17:50
Organizer:Hidehiro Kakizaki Department of Renal and Urologic Surgery, Asahikawa Medical University, Japan
Speakers: Overview of Recent Progress in Neuropharmacology of Lower Urinary Tract Function
Naoki Yoshimura Department of Urology, University of Pittsburgh School of Medicine, USA
The Role of Urothelium in Regulating Lower Urinary Tract Function
Russ Chess-Williams Centre for Urology Research, Bond University, Australia
The Role of Central Nervous System in Regulating Lower Urinary Tract Function
Takahiko Mitsui Department of Urology, Yamanashi University, Japan
Bladder Blood Flow and Lower Urinary Tract Function
Naoki Wada Department of Renal and Urologic Surgery, Asahikawa Medical University, Japan
■ Immunology, Inflammation and Bone Metabolism
Molecular Targets and Imaging Studies in Bone Diseases Wednesday, July 4, 2018   9:25-11:05
Organizer:Hiroshi Takayanagi Department of Immunology Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan
Speakers: RANKL inhibition - bone and beyond
Hiroshi Takayanagi Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan
In vivo visualization of bone cell dynamics
Masaru Ishii Department of Immunology and Cell Biology, Osaka University Graduate School of Medicine, Japan
Application of iPS cell technologies to regenerate articular cartilage damage and model skeletal dysplasia
Noriyuki Tsumaki Center for iPS Cell Research and Application, Kyoto University, Japan
Wnt signaling and bone diseases
Toshimi Michigami Department of Bone and Mineral Research, Osaka Prefectural Hospital Organization, Osaka Women's and Children's Hospital, Japan
Expanding Histamine Research Wednesday, July 4, 2018   15:10-16:50
Organizer:Yuichi Hattori Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
Hiroyuki Fukui Department of Molecular Studies for Incurable Diseases, Tokushima University Graduate School, Japan
Speakers: The Discovery of Histamine H4 Receptor Antagonists for the Treatment of Inflammation
Robin L. Thurmond Janssen Research & Development, LLC, USA
Strategy for the therapy of allergic diseases
Hiroyuki Fukui Department of Molecular Studies for Incurable Diseases, Tokushima University Graduate School, Japan
Roles of Bioactive Lipids in Inflammatory Diseases Thursday, July 5, 2018   9:25-11:05
Organizers:Yukihiko Sugimoto Kumamoto University, Japan
Masataka Majima Department of Pharmacology, Kitasato University School of Medicine, Japan
Speakers: Roles of prostaglandins in inflammatory diseases
Yukihiko Sugimoto Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Japan
Inflammation, Inflammaroty Mediators and Cancer Progression
Raymond N. DuBois The Medical University of South Carolina, USA
TBA
Timothy Hla Harvard Medical School, Boston Children's Hospital, Boston, MA, USA
TBA
Masataka Majima Graduate School of Medical Sciences Kitasato University, Japan
Advances in Molecular Targeting Therapy for Rheumatoid Arthritis Thursday, July 5, 2018   16:10-17:50
Organizer:Masayoshi Harigai Division of Epidemiology and Pharmacoepidemiology, Institute of Rheumatology, Tokyo Women’s Medical University, Japan
Speakers: TNF Inhibitor Treatment of Rheumatoid Arthritis: Orginatiors and Biosimilars
Jonathan Kay Professor of Medicine & Timothy S. and Elaine L. Peterson Chair in Rheumatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Advances of treatment with IL-6/IL-6 receptor inhibitors for RA
Toshihiro Nanki Division of Rheumatology, Department of Internal Medicine, Toho University School of Medicine, Japan
Advances of treatment with kinase inhibitors for RA
Kunihiro Yamaoka Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan
Immunology and Inflammation Friday, July 6, 2018   8:30-10:10
Organizer:Satoshi Uematsu Department of Mucosal Immunology, School of Medicine, Chiba University; Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccine, Institute of Medical Science, The University of Tokyo, Japan
Speakers: TBA
Eicke Latz Institute of Innate Immunity, University Hospital, University of Bonn, Germany
Innate lymphocytes in mucosal Immunity
Marco Colonna Washington University School of Medicine, USA
Posttranscriptional control of immune responses via RNA binding proteins.
Osamu Takeuchi Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Eosinophil depletion is a potential therapeutic strategy for radiation - induced fibrosis in the small intestine
Satoshi Uematsu Department of Mucosal Immunology, School of Medicine, Chiba University; Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccine, Institute of Medical Science, The University of Tokyo, Japan
New Controllers of Inflammation: What Are the Hottest Targets? Friday, July 6, 2018   10:20-12:00
Organizer:Francesca Levi-Schaffer The Hebrew University of Jerusalem, Israel
Speakers: The activating and Inhibitory receptors as pro-inflammatory/ pro- resolutory targets for allergic inflammation.
Francesca Levi-Schaffer‏ The Hebrew University of Jerusalem, Israel
New regulatory checkpoints: Galectins in the control of immune cell homeostasis and inflammation
Santiago P. Mendez-Huergo Immunopathology Lab, Institute of Biology and Experimental Medicine (IBYME-CONICET), Argentina
Mediators of resolution: new kids on the block
Mauro M Teixeira Universidade Federal de Minas Gerais, Brazil
Group 2 innate lymphoid cell and allergic disorders
Kazuyo Moro Laboratory for Innate Immune Systems, RIKEN-IMS, Japan
■ Gastrointestinal System
Translational Research in GI Pharmacology - Novel Therapeutic Strategy in GI Diseases - Wednesday, July 4, 2018   9:25-11:05
Organizer:Koji Takeuchi Kyoto Pharmaceutical University, Japan
Speakers: Why 'cytoprotection' is still relevant: A complex pathophysiologic response or a single mechanism?
Sandor Szabo Department of Pathology & Pharmacology, University of California, Irvine, USA
Therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto.
Toru Kohno Division of Gastroenterologic and General Surgery, Department of Surgery, Asahikawa Medical University, Japan
Cholinergic anti-inflammatory signaling via 5-HT neuron in postoperative ileus.
Masatoshi Hori Department of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
Stress-related modulation of visceral pain: role of CRF signaling
Yvette Taché UCLA Digestive Diseases Division, USA
Present Status and Future Perspective of Gastric Acid Inhibitor Wednesday, July 4, 2018   15:10-16:50
Organizer:Takahisa Furuta Hamamatsu University School of Medicine, Japan
Speakers: Overview of basic and clinical pharmacology of acid inhibitors
George Sachs David Geffen School of Medicine, UCLA, USA
Management of Acid related disorders
Francis K. L. Chan Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Drug-drug interaction associated with gastric acid inhibitors
Takahisa Furuta Center for Clinical Research, Hamamatsu University School of Medicine, Japan
Problems of long-term use of acid inhibitors.
Duan Chen Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Norway
■ Stem Cell Medicine
iPS Cells and Disease Wednesday, July 4, 2018   9:25-11:05
Organizer:Haruhisa Inoue Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan
Speakers: Investigation of ontogenesis and pathogenesis with self-organized brain structure from human iPS cells
Keiko Muguruma RIKEN Center for Developmental Biology (CDB), Japan
Studying for intractable diseases using disease-derived iPS cells
Takumi Era Department of Cell Modulation, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Japan
Kidney regeneration using stem cells
Ryuichi Nishinakamura Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Japan
Dissecting cancer biology with iPS cell technology
Yasuhiro Yamada Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, Japan
Humanized Mouse Models and iPSC as Tools to Study Drug Toxicity Wednesday, July 4, 2018   15:10-16:50
Organizer:Darrell R. Abernethy US Food and Drug Administration/Johns Hopkins University School of Medicine, USA
Speakers: Application of human iPS cells to drug discovery
Hideki Taniguchi Department of Regenerative Medicine, Graduate School of Medicine, Yokohama City University, Japan
The potential of human iPSC-derived hepatocytes as an in vitro tool to characterize drug hepatotoxicity
Chris Goldring MRC Centre for Drug Safety Science, University of Liverpool, Liverpool, UK
Liver Model of Humanized Mice for Evaluation of Drug Hepatotoxicity
Kristina E. Howard U.S. Food & Drug Administration, USA
■ Metabolism and Diabetes
TBA Thursday, July 5, 2018   9:25-11:05
Organizer:Kohjiro Ueki Diabetes and Metabolism Information Center, National Center for Global Health and Medicine, Japan
Role of Mitochondria and Oxidative Stress in Metabolic Syndrome Thursday, July 5, 2018   16:10-17:50
Organizer:Julie Y.H. Chan Kaohsiung Chang Gung Memorial Hospital, Taiwan
Speakers: Developmental Origins of Metabolic Syndrome: Should We Focus on Oxidative Stress?
You-Lin Tain Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Taiwan
Mitochondrial oxidative stress in developmental programming of metabolic syndrome
Julie Y.H. Chan Institute for Translational Research in Biomedical Science, Kaohsiung Chang Gung Memorial Hospital, Taiwan
Role of Cellular Aging in Metabolic Disease
Tohru Minamino Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan
■ Respiratory System
Novel Therapeutic Strategies for Respiratory Diseases Thursday, July 5, 2018   9:25-11:05
Organizer:WS Fred Wong The National University of Singapore, Yong Loo Lin School of Medicine, Singapore
Speakers: Resolution of Lung Inflammation
Alastair Stewart University of Melbourne, Australia
Introduction of treatment concept of "anti-fibrosis" instead of "anti-inflammation" in interstitial lung disease
Arata Azuma Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan
PDE3/4 Inhibitor for Asthma and COPD
Clive Page Sackler Institute of Pulmonary Pharmacology, King's College London, UK
Pharmacological Reversal of Steroid Resistance in Respiratory Diseases
Wai Shiu Fred Wong Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore
■ Systems Biology
Photobiology: Understanding of Biological Systems by Illuminating and
Controlling Biological Functions by Light
Monday, July 2, 2018   9:25-11:05
Organizers:Ryoichiro Kageyama Kyoto University Institute for Virus Research, Japan
Cyril Goudet Institute of Functional Genomics, Montpellier, France
Speakers: Optical control of P2X receptors
Thomas Grutter University of Strasbourg; CNRS, France
Optopharmacological modulation of pain
Cyril Goudet Institute of Functional Genomics, Montpellier, France
Optogenetic control of neural stem cells
Ryoichiro Kageyama Institute for Frontier Life and Medical Sciences, Kyoto University, Japan
Synaptic optogenetics for memory structures
Haruo Kasai Graduate School of Medicine, The University of Tokyo, Japan
Targeting Antioxidant Defence System in Redox Diseases Monday, July 2, 2018   16:10-17:50
Organizer:Mi-Kyoung Kwak The Catholic University of Korea, College of Pharmacy, Korea
Speakers: The Keap1-Nrf2 System for Understanding of Diseases and Drug Development
Masayuki Yamamoto Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Japan
Protective role of NRF2 in hepatocellular carcinoma
Thomas W. Kensler Department of Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA
Regulatory Role of CNC-bZIP Protein NRF1 in Metabolic Homeostasis of Pancreatic beta-cells and Adipocytes
Jingbo Pi School of Public Health, China Medical University, China
Prevention of age-related degenerative diseases by Nrf2-based early intervention
Ken Itoh Hirosaki University Graduate School of Medicine, Department of Stress Response Science, Japan
Understanding Living Systems by Extensive Analyses of All Cells Tuesday, July 3, 2018   9:25-11:05
Organizer:Hiroki R. Ueda Graduate School of Medicine, University of Tokyo/ RIKEN QBiC, Japan
Speakers: Whole-body/organ clearing and imaging with single-cell resolution
Hiroki R. Ueda Graduate School of Medicine, University of Tokyo/ RIKEN QBiC, Japan
Breaking the diffraction limit of light sheets allows fast isotropic imaging of large samples like whole mouse brains by ultramicroscopy
Hans-Ulrich Dodt Technische Universität Wien, Austria
Red and near-infrared reporter proteins for multi-color, multi-cell functional imaging
Robert E. Campbell Department of Chemistry, University of Alberta, Edmonton, AB, Canada
Super-duper multi-color bioluminescent proteins for bioimaging
Takeharu Nagai The Institute of Scientific and Industrial Research, Osaka University, Japan
Systems Biology and Drug Targeting Tuesday, July 3, 2018   15:10-16:50
Organizer:Mariko Okada Laboratory of Cell Systems, Institute for Protein Research, Osaka University, Japan
Speakers: Cellular Variability and Information Flow in Signal Transduction Networks
Roy Wollman University of California - Los Angeles, Department of Integrative Biology and Physiology and Department Chemistry and Biochemistry, Institute of Quantitative and Computational Bioscience, USA
Modeling and validating pharmacological manipulation of circadian rhythms and circadian regulation of p53.
Jae Kyoung Kim Department of Mathematical Sciences, KAIST, Korea
Systems biology of insulin action
Shinya Kuroda Department of Biological Sciences, University of Tokyo, Japan
Modeling of signal-transcriptional network
Mariko Okada Osaka University, Japan
■ Education and Training
European & Asian Training Initiatives to Improve Safe and
Effective Use of Medicines in Modern Healthcare
Monday, July 2, 2018   9:25-11:05
Organizer:Shinichiro Ueda University of the Ryukyus, Japan
Speakers: TBA
Shinichiro Ueda Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus, Japan
Development and experience of the UK Prescribing Safety Assessment (PSA)
Simon Maxwell Clinical Pharmacology Unit, University of Edinburgh, UK
A national web-based, problem oriented course on pharmacotherapy for the elderly for newly graduated physicians
Ylva Böttiger Department of Medical and Health Sciences, Linköping University, Sweden
Introducing the IUPHAR Pharmacology Education Project - www.pharmacologyeducation.org Monday, July 2, 2018   16:10-17:50
Organizer:John L. Szarek Geisinger Commonwealth School of Medicine, USA
Speakers: From Idea to Reality
Simon Maxwell Clinical Pharmacology Unit, University of Edinburgh, UK
Taxonomy and structure of the Pharmacology Education Project website
John L. Szarek Geisinger Commonwealth School of Medicine, USA
Pharmacology teaching materials for resource-poor countries
Leszek Wojnowski Department of Pharmacology, University Medical Center, Johannes Gutenberg-Universität Mainz, Germany
Navigating the Pharmacology Education Project website – Using materials in teaching
Elizabeth Davis Monash University, Australia
The Pharmacology Education Project – An international effort
Chay-Hoon Tan National University of Singapore, Singapore
Experiences and Models for Strengthening Pharmacological Research,
Teaching and Services in Resource Strained Countries
Tuesday, July 3, 2018   9:25-11:05
Organizer:Collen Masimirembwa African Institute of Biomedical Science & Technology (AiBST), Zimbabwe
Speakers: Laboratory based pharmacological research and training in Africa: experiences, clinical links and the potentials of ICT
Collen Masimirembwa African Institute of Biomedical Science and Technology, Zimbabwe
Basic and Clinical Pharmacology in the TRES Paradigm (Teaching, Research, Entrepreneurship, and Service) for developing Africa: concept, results, and sustainability
Theresa Adebola John Department of Pharmacology, Lagos State University College of Medicine (LASUCOM), Lagos, Nigeria
Present and future IUPHAR plans for network support in training and capacity building in pharmacology and clinical pharmacology in resource strained countries
Michael Spedding IUPHAR and Spedding Research Solutions SAS, France
Clinical Trials Research and Services Capacity in Sub-Saharan Africa
Bernhards Ogutu Ragama Strathmore University / Kenya Medical Research Institute, Kenya
IPE: Educating a New Generation of Healthcare Professionals to
Prescribe Medications Safely and Effectively
Tuesday, July 3, 2018   15:10-16:50
Organizer:Kelly Karpa Pennsylvania State University College of Medicine, USA
Speakers: What is IPE and why does it matter?
Mayumi Willgerodt Univeristy of Washington, USA
Impact of IPE: How it changed students during a Clinical Pharmacology Curriculum
Kelly Karpa Pennsylvania State University College of Medicine, USA
IPE in clinical pharmacology education and influence at the bed side
Itsuko Ishii Division of Pharmacy, Chiba University Hospital, Japan
Overview of an IPE program in a university in Madrid
Carlo Bressa European University, Spain
■ Sensory System
Frontiers in Approaching Retinal Research - The Current Status and Future in
Development of Therapeutic Strategies Based on Genetic and iPS Methods-
Tuesday, July 3, 2018   9:25-11:05
Organizer:Hideaki Hara Gifu Pharmaceutical University, Molecular Pharmacology , Japan
Speakers: Characterization and future direction of human induced pluripotent stem cell-derived retinal pigment epithelial cell sheets
Masayo Takahashi RIKEN Center for Developmental Biology, Laboratory for Retinal Regeneration, Japan
Development of the innovative therapies utilizing human induced pluripotent stem cell technology
Hardy T.S. Kagimoto HEALIOS K.K., Japan
Lessons from KO mice of the genes regulating retinal photoreceptor development and function
Takahisa Furukawa Institute for Protein Research, Osaka University, Japan
The challenge of transplantation: The intricate structure and function of the cone photoreceptor synapse
Steven H. DeVries Departments of Ophthalmology and Physiology, Northwestern University, Feinberg School of Medicine, USA
■ Cancer
Cancer Drug Resistance Tuesday, July 3, 2018   9:25-11:05
Organizer:Mi-Kyoung Kwak The Catholic University of Korea, College of Pharmacy, Korea
Speakers: Role of the IGF Axis in Lung Carcinogenesis: Novel strategies for Lung Cancer Prevention and Therapy
Ho-Young Lee College of Pharmacy, Seoul National University, Seoul, Korea
Metabolic reprogramming and cell fate decision of tumor-initiating stem-like cells
Keigo Machida University of Southern California Keck School of Medicine, USA
Role of Nrf2 in drug resistance of cancer stem-like cells
Mi-Kyoung Kwak College of Pharmacy, The Catholic University of Korea, Korea
NRF2 contribution to proliferation and tumorigenesis of cancer cells
Hozumi Motohashi Department of Gene Expression Regulation, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Japan
Novel Targets and Biomarkers for Anticancer Therapeutics Tuesday, July 3, 2018   15:10-16:50
Organizer:Atsushi Ohtsu National Cancer Center Japan, Japan
Speakers: Role of regulatory T cells as a perdictive markers in immuno-oncology
Hiroyoshi Nishikawa Department of Immunology, Nagoya University Graduate School of Medicine/Division of Cancer Immunology Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Japan
Clinical utility of integrated clinical and genomic data for colorectal cancers
Woong-Yang Park Samsung Genome Institute, Samsung Medical Center, Seoul, Korea
New targetes and biomarkers in hematological malignancies
Seishi Ogawa Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University , Japan
Clinical implication of liquid biopsy in conology
Simon Joosse University Medical Center Hamburg-Eppendorf, Germany
■ Rare Diseases
Therapeutic Manipulation of RNA/DNA for Genetic Diseases Tuesday, July 3, 2018   15:10-16:50
Organizer:Masatoshi Hagiwara Department of Anatomy and Developmental Biology, Kyoto University Graduate School of Medicine, Japan
Speakers: New therapeutis for Pompe disease
WWM Pim Pijnappel Erasmus Medical Center, Rotterdam, The Netherlands
New therapeutis for Fabry
Masatoshi Hagiwara Kyoto University, Japan
Nusinersen (SpinrazaTM): The First FDA-Approved Drug for Spinal Muscular Atrophy
Adrian R. Krainer Cold Spring Harbor Laborartory, USA
■ Molecular Bioimaging
Multidisciplinary Approach on Molecular Bio-imaging from
Basic to Clinical Pharmacological Studies
Thursday, July 5, 2018   16:10-17:50
Organizer:Kazuhiko Yanai Department of Pharmacology, Tohoku University School of Medicine, Japan
Chairs:Samuel H.H. Chan Institute for Translational Research in Biomedicine, Chang Gung Memorial Hospital, Taiwan
Kazuhiko Yanai Department of Pharmacology, Tohoku University School of Medicine, Japan
Speakers: Novel Fluorogenic Probes for Intraoperative Rapid Imaging of Tiny Tumors
Yasuteru Urano The University of Tokyo, Japan
Application of neuroimaging to neuropsychiatric diseases, including imaging biomarkers that may predict treatment response
Wen-Yih Isaac Tseng Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taiwan
In vivo imaging of proteinopathies
Victor Villemagne University of Melbourne, Australia
■ Infection/Global Infectious Diseases
Optimising Drug Selection and Dosage in Treating Infectious Diseases in
Children and Pregnant Women in Africa
Tuesday, July 3, 2018   9:25-11:05
Organizer:Lars L. Gustafsson Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Sweden
Speakers: Therapeutics ror Drug-susceptible and Drug-Resistant TB Pregnant Woman and in Children
Anneke C. Hesseling Desmond Tutu TB Centre, Department of Paediatris and Child Health, Stellenbosch Univesity, South Africa
Modelling approaches to optimize mono- and combination therapies for neglected tropical diseases in children
Thomas Dorlo Department of Pharmacy & Pharmacology, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Optimal drug therapies for HIV in pregnant women and in children: considering pharmacogenetics and drug-drug interactions
Helen McIlleron University of Cape Town, Cape Town, South Africa
Multifaceted research and implementing approaches to control emerging resistance for HIV-, malaria- and tb-therapy in children and pregnant women
Lars L. Gustafsson Division of Clinical Pharmacology, Department of Laboratory Medicine, Karolinska Institutet, Sweden
New Drugs for Emerging Infectious Disease Tuesday, July 3, 2018   15:10-16:50
Organizer:Mauro M. Teixeira Department Biochemistry and Immunology, Universidade Federal de Minas Gerais, Brazil
Timothy Wells Medicines for Malaria Venture, Switzerland
Speakers: A Broad-Spectrum Antiviral Peptide for Combating Emerging Viral Pathogens
Nam-Joon Cho School of Materials Science and Engineering, Nanyang Technological University, Singapore
Structural biology, drug design and discovery targeting Zika virus non-structural proteins
Glaucius Oliva University of São Pualo, Brazil
Open Source collaborations to identify new leads for Neglected Disease Drug Discovery
Timothy N Wells Medicines for Malaria Venture, Geneva , Switzerland
Vaccine Drug Diagnostic Development for the Control of Emerging Infectious Diseases Wednesday, July 4, 2018   9:25-11:05
Organizer:Kouichi Morita NEKKEN, Nagasaki University, Japan
Speakers: Live attenuated dengue vaccine development: experience of Mahidol University
Sutee Yoksane Center for Vaccine Development, Institute of Molecular Biosciences, Mahidol University, Thailand
Rapid Diagnostics for Ebola virus disease
Jiro Yasuda Department of Emerging Infectious Diseases, Institute of Tropical Medicine, Nagasaki University, Japan
Antiviral activity of favipiravir against rabies virus infection
Akira Nishizono Department of Microbiology, Faculty of Medicine, Oita University, Japan
Rapid Diagnostic for Zika virus infection
Kazuyoshi Miyamoto UBE Research and Development Group, Fundamental Research Department, Research and Development Division, Fujirebio Inc., Japan
All for Global Health, Global Health for All Wednesday, July 4, 2018   15:10-16:50
Organizer:Kenji Hirayama NEKKEN、Nagasaki University, Japan
Speakers: Japanese original fundamental technology for diagnostics of infection
Tsugunori Notomi Biochemical Research Laboratory-II, Eiken Chemical Co., Ltd, Japan
■ Natural Medicine and Traditional East Asian Medicines
Ameliorating Effects of Traditional Chinese Medicine on Ischemia/Reperfusion-induced
Cerebral Microcirculatory Disturbances and Neuron Damage
Wednesday, July 4, 2018   9:25-11:05
Organizer:Jing-Yan Han Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences Peking University, China
Speakers: Oxidative Stress and Antioxidant: What We Should Do for Brain Damage and Brain Repair and Its Implication in Stroke Treatment
Jiangang Shen School of Chinese Medicine, University of Hong Kong, Hong Kong, China
A possible role of linkage between cholinergic and vascular endothelial growth factor (VEGF) systems in anti-dementia effects of traditional Chinese and Kampo medicines
Kinzo Matsumoto Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, Japan
Multi-target effects of 3-n-Butylphalide, a component of Apium graveolens L., in treatment of neurodegenerative diseases.
Xiaoliang Wang Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Ameliorating effects of traditional Chinese medicine on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage
Jing-Yan Han Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, China
Globalization of Traditional Asian Medicine Wednesday, July 4, 2018   15:10-16:50
Organizer:Haruki Yamada Kitasato University, Japan
Speakers: Recent Progress in Clinical and Basic Research of the Japanese Kampo Medicine
Kazushige Mizoguchi Tsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Japan
The Pharmacological and Clinical Evidences of a Multi-herbal Drug Product - Dantonic(T89) Indicated for the Prevention and Treatment of Chronic Stable Angina - for FDA Registration
Henry Sun Tasly Holding Group Co.Ltd. / Tasly Pharmaceuticals, Inc.; Columbia University, Center for TMC Research, NY, USA
Recent Clinical Trials of Korean Red Ginseng
Young Jack Lee LSK Global Pharma Services Co,.Ltd., Korea
The First New Botanical Drug Approved in Taiwan--PG2 Injection
Chien-Hsin Daniel Cheng Phytohealth Corporation, Taiwan
Pharmacological Investigation in New Drug Discovery Thursday, July 5, 2018   16:10-17:50
Organizer:Guanhua Du Institute of Materia Medica, Chinese Academy of Medical Sciences, China
Speakers: Phenotypical versus target-based screening in CNS disorders: new directions for much-needed breakthroughs
Michael Spedding IUPHAR and Spedding Research Solutions SAS, France
How regulatory aspects shape preclinical and clinical research
Daniel Hoyer Department of Pharmacology & Therapeutics, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia
Anticancer Effects and Mechanisms of MAM, a Natural Naphthoquinone
Xiuping Chen University of Macau, Macau, China
Drug discovery form Natural products and traditional medicine, strategy and application
Guanhua Du Institute of Materia Medica, Chinese Academy of Medical Sciences, China
Network Pharmacology Friday, July 6, 2018   8:30-10:10
Organizer:Wenxia Zhou Beijing Institute of Pharmacology and Toxicology, China
Speakers: PheWAS and Pharmacophenomics in Precision Medicine and Traditional Chinese Medicine
Dayue Darrel Duan University of Nevada Reno School of Medicine, USA
Network pharmacology based study of LW-AFC, a new formula from a traditional Chinese medicinal prescription, on neuroendocrine immunomodulation network
Wenxia Zhou Beijing Institute of Pharmacology and Toxicology, China
Indication expansion and drug positioning -- opportunities for translational sciences
Lun Yang Deputy Director, Indication Expansion, Bayer AG, Germany
■ Regulatory Science
Global Clinical Trials and Ethnic Factors Tuesday, July 3, 2018   9:25-11:05
Organizer:Masahiro Tohkin Nagoya City University Graduate School of Pharmaceutical Sciences, Japan
Speakers: Ethnic difference in drug response; pharmacokinetics, efficacy, and safety
Masahiro Tohkin Nagoya City University Graduate School of Pharmaceutical Sciences, Japan
Co-operative activity for the clinical study in East Asia region
In-Jing Jang Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Korea
Regional variability and efficient drug development based on ICH E17 guideline; multi-regional clinical trials
Yoshiaki Uyama Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Japan
The trend of global clinical trials - Implications of ICH E17
Inger Mollerup Novo Nordisk A/S, Denmark
■ Pharmacovigilance
Role of Database Study in Pharmacovigilance Wednesday, July 4, 2018   9:25-11:05
Organizer:Kiyoshi Kubota NPO Drug Safety Research Unit Japan, Japan
Speakers: How secondary healthcare data could contribute to bridging the knowledge gap after a medical product is approved
K. Arnold Chan National Taiwan University, Health Data Research Center, Taiwan
Post-authorisation safety studies and databases in the EU
Stella Blackburn QuintilesIMS, UK
Regulatory perspective on drug safety assessment based on real world data in Japan
Yoshiaki Uyama Office of Medical Informatics and Epidemiology, Pharmaceuticals and Medical Devices Agency, Japan
Database studies in post-marketing surveillance in Japan: Perspective from the industry
Kotonari Aoki Real World Data Science Department, Chugai Pharmaceutical Co., LTD., Japan
■ Health Economics
Health Technology Assessment (HTA) for Smaller Countries:
The Central Role of Clinical Pharmacology
Tuesday, July 3, 2018   9:25-11:05
Organizers:Phil Routledge Cardiff University, UK
David J. Webb University of Edinburgh, UK
Speakers: Health Technology Assessment (HTA) for Smaller Countries: The role of the health economist
Dyfrig Hughes Centre for Health Economics and Medicines Evaluation, Ardudwy, Bangor University, UK
The role of the clinical pharmacologist
David J. Webb Christison Professor of Therapeutics & Clinical Pharmacology, The University of Edinburgh, Scotland, UK
The role of the pharmacist and access issues
Karen Samuels Head of Patient Access to Medicines Service, All Wales Therapeutics & Toxicology Centre, Academic Centre, University Hospital Llandough, UK
How this works effectively in practice
Ken Paterson University of Glasgow, Glasgow, Scotland, UK
■ Toxicology
Novel Biomarkers, Predictors and Models for Drug-induced Liver Injury Friday, July 6, 2018   8:30-10:10
Organizer:Daniel J. Antoine University of Liverpool, UK
Speakers: Novel biomarkers and therapeutic interventions for DILI
Daniel J. Antoine University of Liverpool, UK
Genetic risk factors for DILI-recent findings from large international networks
Ann K. Daly Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Toxicogenomics for Accelerated and Refined Hazard Identification of Chemicals
(Joint Symposium between IUTOX and IUPHAR)
Friday, July 6, 2018   10:20-12:00
Organizer:Jun Kanno Japan Bioassay Research Center Japan Organization of Occupational Health and Safety, Japan
Speakers: Does exposure to hazardous chemicals activate distinct toxicity signaling pathways in germ cells and embryos?
Barbara F. Hales Department of Pharmacology and Therapeutics, McGill University, Canada
Percellome Toxicogenomics Project for the prediction of acute and chronic toxicity
Jun Kanno Japan Bioassay Research Center, Japan Organization of Occupational Health and Safety, Japan
Persistent transcriptional responses show the involvement of feed-forward control in a repeated dose toxicity study
Jos Kleinjans Maastricht University, The Netherlands
AI-driven systems toxicology
Hiroaki Kitano The Systems Biology Institute, Japan
■ Genomics/Pharmacogenomics / Personalized Medicine
Pharmacogenomics in Special Populations Wednesday, July 4, 2018   9:25-11:05
Organizers:Guilherme Suarez-Kurtz Brazilian Pharmacogenomics Network, Brazil
Andrew Somogyi University of Adelaide, Australia
Speakers: Pharmacogenetics in the Oceania region: precision medicine challenges
Andrew Somogyi University of Adelaide, Australia
African Pharmacogenomics Research Consortium: Focus on HIV, Tuberculosis and Malaria treatment
Eleni Aklillu Department of Laboratory of Medicine, Karolinska Institutee Stockholm, Sweden
Pharmacogenomic implications of population admixture in the Americas
Guilherme Suarez-Kurtz Brazilian Pharmacogenomics Network, Brazil
Pharmacogenomic research and its implementation in Asian region
Yoshiro Saito National Institute of Health Sciences, Division of Medicinal Safety, Japan
Pharmacogenomics in Drug Therapy; Future Perspective, Next Generation of Pharmacogenomics Thursday, July 5, 2018   9:25-11:05
Organizer:Ichiro Ieiri Kyushu University, Japan
Speakers: pharmacogenomcs of drug metabolizing enzymes for personalized precision pharmacotherapy
Jae-Gook Shin PharmacoGenomics Research Center, Inje University College of Medicine, Korea
Genomics of Transporters: Implications to Drug Discovery, Development and Response
Kathy Giacomini Department of Bioengineering and Therapeutic Sciences, University of California, San Francisc, CA, USA
microRNA-SNPs as biomarkers of drug response and toxicity
Miki Nakajima Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
Challenges for application of epigenetic concepts to pharmacogenomics in humans
Ichiro Ieiri Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Nuclear Receptors as Therapeutic Targets Thursday, July 5, 2018   16:10-17:50
Organizer:InKyeom Kim Kyungpook National University School of Medicine, Korea
Speakers: Better control of inflammation by harnessing biased signalling at the glucocorticoid receptor or targeting other nuclear receptors?
Christine Keenan The Walter and Eliza Hall Institute of Medical Research, Australia
Ubiquitylation of nuclear receptors: therapeutic implications
Elaine T. Alarid Department of Oncology, University of Wisconsin Carbone Comprehensive Cancer Center; University of Wisconsin-Madison, USA
Inhibition of Deubiquitinating Enzyme USP7 :a potential therapeutic strategy for prostate cancer
Shu-Ting Chen Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
Histone deacetylase inhibitors as novel therapeutics in cardiometabolic syndrome
InKyeom Kim Department of Pharmacology, Kyungpook National University School of Medicine, Korea
■ Pharmacometrics
Horizon of PMx Tuesday, July 3, 2018   9:25-11:05
Organizer:Yuji Kumagaya Kitasato University Hospital Clinical Trial Center, Japan
Speakers: Novel PBPK approaches
Yuichi Sugiyama Sugiyama Laboratory, RIKEN Innovation Center, Japan
A Pharmacodynamic Model of Tumor Progression and Survival in HER2 Positive Metastatic Gastric Cancer Patients treated with Trastuzumab and Chemotherapy
Kyungsoo Park Department of Pharmacology, Yonsei University College of Medicine, Korea
Model-based drug development
Ryosei Kawai Clinical Science Japan, Bayer Yakuhin Ltd., Japan
■ Pharmacokinetics
Recent Progress of Immunosuppressant TDM Wednesday, July 4, 2018   9:25-11:05
Organizer:Satohiro Masuda Department of Pharmacy, Kyushu University Hospital, Japan
Speakers: Progress of Immunosuppressive regimen after kidney transplantation
Dennis A. Hesselink Erasmus MC, University Medical Center Rotterdam, The Netherlands
Role of mTOR inhibitors in solid organ transplantation
Satohiro Masuda Department of Pharmacy, Kyushu University Hospital, Japan
Pharmacometric analysis of immunosuppressive drugs in pediatric transplant patients
Tsuyoshi Fukuda Cincinnati Children's Hospital Medical Center/Department of Pediatrics, University of Cincinnati College of Medicine, USA
Immunosuppressive therapy in organ transplantation: Strategies for personalization approaches
Hideki Ohdan Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical & Health Sciences, Hiroshima University, Japan
Pharmacokinetic/-dynamic Modelling
- Population PK/PD-models
- Physiology-based PK (PBPK) Models
- PK/PD models: Application in Paediatrics
- PB/PK-modelling: Regulatory Aspects
Wednesday, July 4, 2018   15:10-16:50
Organizer:Petra A. Thurmann University Witten/Herdecke, HELIOS Hospital Wuppertal, Germany
Speakers: Physiologically-based Pharmacokinetic Modelling in Drug Development: A View from the Pharmaceutical Industry
Stefan Willmann Clinical Pharmacometrics, Bayer AG, Wuppertal , Germany
Pharmacokinetic Pharmacodynamic Modeling for Pediatric Drug Dosing
Hanneke van der Lee Emma Children's Hospital, Academic Medical Center Amsterdam, The Netherlands
Population Physiologically Based Pharmacokinetic Models for Macromolecular Drugs
Andrea N. Edginton School of Pharmacy, University of Waterloo, Canada
PBPK application: from academic research to routine use in drug development and regulation
Ping Zhao Quantitative Sciences, Global Health - Integrated Development, Bill and Melinda Gates Foundation, USA
The Prediction of Renal Drug Transport: A Story with Many Tales Thursday, July 5, 2018   9:25-11:05
Organizer:Rosalinde Masereeuw Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, The Netherlands
Speakers: Innovative tools for studying renal drug transport and associated interactions
Rosalinde Masereeuw Div. Pharmacology, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, The Netherlands
Kinetic and molecular analysis of renal drug-drug interactions
Hiroyuki Kusuhara Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
Interorgan crosstalk involved in renal drug and metabolite handling
Sanjay K. Nigam University of California San Diego, USA
In vitro to in vivo extrapolation of renal drug clearance within physiologically-based pharmacokinetic paradigm
Alexandra Galetin Centre for Applied Pharmacokinetic Research, The University of Manchester, School of Health Sciences, UK
■ Pediatric Clinical Pharmacology
Innovative Apprach to Pediatric Drug Development and Clinical Practice
Topics Include Pharmacogenomics, Pharmacometrics and New Formulations.
Tuesday, July 3, 2018   15:10-16:50
Organizer:Hidefumi Nakamura National Center for Child Health and Development, Japan
Speakers: Pharmacometrics in children
Tsuyoshi Fukuda Cincinnati Children's Hospital Medical Center/Department of Pediatrics, University of Cincinnati College of Medicine, USA
Pharmacogenomics in children
Sara Van Driest Vanderbilt University School of Medicine, Nashville, TN, USA
Pediatric Formulation
Catherine Tuleu University College London School of Pharmacy, UK
■ Industry-Academia Collaboration
Open Innovation for Drug Discovery Monday, July 2, 2018   16:10-17:50
Organizer:Chikako Saotome Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Japan
Speakers: Alliance strategy of Bayer
Shunichi Takahashi Open Innovation Center Japan, Bayer Yakuhin, Ltd., Japan
Open Innovation for Drug Discovery in Japan
Yoshinori Ikeura Takeda Pharmaceutical Company, Ltd., Japan
From bench to bedside, how to translate academic research and drug development
Daria Mochly-Rosen Stanford Universtiy School of Medicine, USA
■ Cross-Sectoral
The BPS Focus on Pharmacology Project:
Securing the Future of Pharmacology & Clinical Pharmacology
Tuesday, July 3, 2018   15:10-16:50
Organizers:David J. Webb University of Edinburgh, UK
 Jonathan Bruun British Pharmacological Society, UK
Speakers: The problem with Pharmacology: The need for audit and impact
David J. Webb Christison Professor of Therapeutics & Clinical Pharmacology, The University of Edinburgh, Scotland, UK
Developing research projects to demonstrate the value and impact of pharmacology and clinical pharmacology
Anna Y. Zecharia British Pharmacological Society, UK
Methods for the development of curricula in pharmacology, the BPS experience
Melisa ‘Lisa’ Wallace Academic Development, British Pharmacological Society; Swansea University, UK
Results: The impact of the Focus on Pharmacology project, and its implications for the global pharmacology community
Stephen J. Hill University of Nottingham & British Pharmacological Society, UK
Nutrient and Metabolite Sensing by GPCRs Wednesday, July 4, 2018   15:10-16:50
Organizers:Kazuwa Nakao Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan
Stefan Offermanns Max Planck Institute for Heart and Lung Research, Germany
Speakers: Translational Science on regulation of hormone receptor sensitivities by nutrients
Kazuwa Nakao Medical Innovation Center, Kyoto University Graduate School of Medicine, Japan
Autocrine Regulation of Metabolic Functions Through Metabolite GPCRs
Stefan Offermanns Max Planck Institute for Heart and Lung Research, Bad Nauheim; Medical Faculty, University of Frankfurt am Main, Germany
Long-chain fatty-acid receptors and pancreatic islet function
Vincent Poitout University of Montreal, Canada
Novel ligands for metabolite receptors
Thue W. Schwartz University of Copenhagen, Denmark
Molecular Pharmacology Focused Studies of Calcium Permeable Ion Channels:
Identifying New Pharmacological Targets and Therapies
Thursday, July 5, 2018   9:25-11:05
Organizer:Gregory R. Monteith The School of Pharmacy, The University of Queensland, Australia
Speakers: Calcium permeable ion channels and cell death pathways in breast cancer cells
Gregory R. Monteith The University of Queensland, Australia
Consequences of ion channel remodelling in prostate cancer
Natalia Prevarskaya University of Lille 1, Inserm, France
Ryanodine receptor Ca2+ release channels and cardiac arrhythmia
Nagomi Kurebayashi Cellular and Molecular Pharmacology, Faculty of Medicine, Juntendo University , Japan
Calcium channel pain targets: insights from toxins
Irina Vetter The University of Queensland, Australia
3D Microtissues in Drug Discovery: Mechanopharmacology Friday, July 6, 2018   8:30-10:10
Organizer:Alastair Stewart Department of Pharmacology and Therapeutics, University of Melbourne, Australia
Speakers: Pharmacology on-a-chip (will be updated in a few weeks 5/24)
Geraldine Hamilton Emulate, Inc., USA
Getting the right traction for anti-fibrotic drug evaluation
Alastair Stewart University of Melbourne, Australia
Liquid Biopsy and the Expansion of Patient Derived Circulating Tumor Cell Spheroids for Precision Medicine
Chwee Teck Lim National University of Singapore, Singapore
Microfluidic Technologies toward Pharmakokinetics on a Chip
Teruo Fujii Institute of Industrial Science, The University of Tokyo, Japan
Cutting Edge Assay Technologies for Studying Molecular and
Cellular Pharmacology (Joint Symposium between BPS and ASCPT)
Friday, July 6, 2018   8:30-10:10
Organizers:Kevin Pfleger Harry Perkins Institute of Medical Research, Australia
Michelle L. Halls Monash Institute of Pharmaceutical Sciences, Monash University, Australia
Speakers: Cellular imaging technologies
Atsushi Miyawaki RIKEN Brain Science Institute/ RIKEN Center for Advanced Photonics, Japan
Understanding spatial and temporal control of GPCR signalling using fluorescence and bioluminescence
Michelle L. Halls Monash Institute of Pharmaceutical Sciences, Monash University, Australia
Fluorescence and bioluminescence approaches to study ligand binding to GPCRs and RTKs
Stephen J. Hill University of Nottingham & British Pharmacological Society, UK
Utilising BRET to decipher the complexities of cellular signalling
Elizabeth Johnstone Harry Perkins Institute of Medical Research and The University of Western Australia, Australia
Computational Pharmacology, Databases and Drug Discovery Friday, July 6, 2018   10:20-12:00
Organizers:David Gloriam University of Copenhagen, Denmark
 Adam Pawson University of Edinburgh, UK
Speakers: The Guide to PHARMACOLOGY druggable genome coverage
Christopher Southan IUPHAR/BPS Guide to PHARMACOLOGY, Centre for Integrative Physiology, University of Edinburgh, Scotland
The G protein-coupled receptor database, GPCRdb
David Gloriam University of Copenhagen, Denmark
A new database for kinase-oriented phospho-proteomics: KANPHOS
Kozo Kaibuchi Nagoya University Graduate School of Medicine, Japan
Illuminating the druggable GPCR-ome
Bryan L. Roth Department of Pharmacology, University of North Carolina at Chapel Hill, USA
System Pharmacology of the AMPK-activated Protein Kinase Friday, July 6, 2018   10:20-12:00
Organizers:A. Mark Evans University of Edinburgh, UK
 D. Graham Hardie University of Dundee, UK
Speakers: AMPK pharmacology and cancer
D. Grahame Hardie Division of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, UK
Small molecule modulators of AMPK and diabetes
Kei Sakamoto Nestlé Institute of Health Sciences, Switzerland
AMPK activators in the treatment of liver diseases
Gregory Steinberg McMaster University, Canada
AMPK-dependent modulation of breathing and oxygen supply: an emerging therapeutic strategy for sleep apnoea and pulmonary hypertension?
A. Mark Evans Centre for Integrative Physiology, Edinburgh Medical School: Biomedical Sciences, University of Edinburgh, Edinburgh, UK
New Insight into Aquaporin Function as Drug Targets Friday, July 6, 2018   10:20-12:00
Organizer:Masato Yasui Keio University School of Medicine, Japan
Speakers: Aquaporin-mediated water permeation drives tumor cell migration
Konstantinos Konstantopoulos Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, USA
Role of AQP4 in skeletal muscle
Antonio Frigeri Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari-Aldo Moro Medical School, Bari, Italy
Role of Aquaporin 3 in hydrogen peroxide transport and cellular signaling
Mariko Hara-Chikuma School of Medicine, Keio University, Japan
Molecular physiology of renal aquaporin-2 and its role in water balance disorders
Tae-Hwan Kwon Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Korea
■ Miscellaneous
GPCR and RhoA Signaling in Physiology and Disease Friday, July 6, 2018   8:30-10:10
Organizer:Joan Heller Brown Department of Pharmacology, University of California, USA
Speakers: RhoA-mediated transcriptional pathways in tumor cell growth
Joan Heller Brown Department of Pharmacology, University of California San Diego, La Jolla, CA, USA
RhoA in cardiac remodeling
Mikito Takefuji Nagoya University Graduate School of Medicine, Japan
RhoA in cardioprotection and mitophagy
Shigeki Miyamoto Department of Pharmacology, University of California San Diego, USA
RhoA-induced MRTFA activation in fibrotic disease
Richard R. Neubig Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI, USA
Rho kinase in metabolic disorders
Hiroaki Shimokawa Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Japan
Biased Agonism at G Protein-coupled Receptors: The Promise and the Challenges Friday, July 6, 2018   10:20-12:00
Organizer:Anthony P. Davenport Experimental Medicine and Immunotherapeutics, University of Cambridge, UK
Speakers: Biased apelin receptor agonists for cardiovascular disease
Anthony P. Davenport Experimental Medicine and Immunotherapeutics, University of Cambridge, UK
Biasing GPCR signalling via the phosphorylation barcode
Andrew A. Tobin University of Glasgow, UK
Spatiotemporal signalling in G-protien coupled receptors
Martin Lohse Max-Delbrück-Centrum für Molekulare Medizin, Berlin, Germany
Biased agonism and opioid receptor-mediated analgesia
Laura M. Bohn The Scripps Research Institute, USA
■ Pharmacology for Africa
African Indigenous Biodiversity: Gateway for Discovery Tuesday, July 3, 2018   9:25-11:05
Organizer:Douglas Oliver Pharmacology for Africa, South Africa
Speakers: African molecular diversity for library design and discovery
Douglas Oliver Chair of Pharmacology for Africa, South Africa
Advances in African traditional medicines
Anastasia Nkatha Guantai Kenyan Society for Basic and Applied Pharmacology (KESoBAP), Kenya
From concept to clinic: An African experience with herbal medicines
Mohamed T. Khayyal Department of Pharmacology, Faculty of Pharmacy, Cairo University, Egypt
Opportunities for vaccine development: an African approach
Alexander Nii Oto Dodoo University of Ghana School of Medicine and Dentistry, Ghana

Oral Communications & Posters

Oral presentations and posters are planned for the 6-day conference.

Congress Secretariat

c/o Congress Corporation
Kohsai-kaikan Bldg., 5-1 Kojimachi,Chiyoda-ku, Tokyo 102-8481, Japan
TEL: +81-3-5216-5318 FAX: +81-3-5216-5552 E-mail: wcp2018@congre.co.jp