Takashi Kadowaki

Takashi Kadowaki, MD, PhD

Takashi Kadowaki is currently Professor and Chairman of the Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, at the University of Tokyo. His major research interests include molecular basis of insulin resistance and type 2 diabetes and molecular mechanisms of adiponectin action and adiponectin receptors. Using gene targeting strategy, his laboratory determined the physiological roles of key molecules in insulin secretion and insulin action such as β-cell glucokinase and NADH shuttle and insulin receptor substrate-1, P85α PI3 kinase and PPARγ, respectively. His laboratory discovered insulin sensitizing effect of adiponectin and identified and cloned receptors for adiponectin, AdipoR1 and AdipoR2. Moreover, his laboratory revealed the physiolocal roles of AdipoR1 and AdipoR2 in liver, skeletal muscle and other tissues and the pathophysiological roles of reduced adiponectin effects in obesity-linked diseases such as type2 diabetes. More recently, his laboratory identified agonists for adiponectin receptors (AdipoRon) and also revealed the 3D structure of human AdipoR1 and AdipoR2. He served as an editorial board member of Diabetes , Diabetologia and Journal of Clinical Investigation and currently is on the editorial board of Cell Metabolism and Molecular Metabolism.